Peptidases • Archaeplastida
Annotations/GenomesAraly1Astpho2Auxeprot1Batpra1ChlNC64A_1Chlre4Chocri1Chrzof1Coc_C169_1Cyamer1Dicre1Dunsal1Galsul1Gonpec1MicpuC3v2MicpuN3v2Monneg1Ost9901_3OstRCC809_2Ostta1115_2Ostta4221_3Phypa1_1Picsp_1Poptr1_1Porumb1Rapsub1SceoblEN4_1Selmo1Sobl393_1Sorbi1SymretAf1SymretSc1SymretSp1SymretSw1Volca1TotalAnnotation Description
Merops
6532721931553092871823152711353062801952771761983582291021731661662162572983662982943052813258,038
554222369731119212542222429991194193Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
733233323142223345333263234443398Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11111211110Water nucleophile; water bound by two Asp
6625171625291921201724191820191932301015191591420272523292526693Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
15313325165411311113424567674105Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2311132412225111121213233463Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
41111111111111118Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11111121111113Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
52222211113223322233112112222260Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
20544644563545534233334553455556148Families of peptidase inhibitors not assigned to clans
112
2114
55
521141111245129
211111112111115
6111110
1113
111211111111111117
11
162111171122
44
412212321233222234
11
111115
333225313241312131211121122258Families of metallopeptidases not assigned to clans
121184244492511615141144982884859131525331415141588549Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
3522341643434492222224742332296Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
23111242267341111211113143433179Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
3131222412134222522262231111164Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
16666756986888656994656789788888226Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
2113568109111041210612561353853479121213121112277Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
465896496211649495624465557111112118204Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
653233244223232233322242311111279Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
112111213215Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
8834435364475354553543444445443137Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
211111321211111211112221111137Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
6423257612548438771972461223119799978253Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
3428181625182025212621182719202227229161918282522292521242119683Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
1311858961110461287569534547961476767228Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
24212113786643Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11212121121116Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
5384113396773311111112136253966665247Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
218746144767436958221897430685057100642750454128859110385848480642,180Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
11211331111222123Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
9451434365647124233323255657653128Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111111111110Serine nucleophile; catalytic residues in the order His, Ser, His in sequence
11122211123113121211111235Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1717101012101012169191091189121171310108101316181519168375Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1111111119Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
15118Serine nucleophile; catalytic residues in the order Lys, Ser in sequence
20856583774869769472566363488777201Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
1449Families of peptidases of unknown catalytic mechanism not assigned to clans
4331314978472413102312935645151646311205
314
11
123