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Peptidases • Alveolata
Annotations/GenomesOxytri1Partet1Plafal1Symmic1Tetthe1Toxgon1TotalAnnotation Description
Merops
33267787195470741,835
11Families of aspartic peptidases not assigned to clans
27411013475143Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
2812114Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
731648201345404Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
4313617Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
1214Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
12238Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
15219Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Water nucleophile; water bound by Gln and Glu; all endopeptidases
31114Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
1127437456Families of peptidase inhibitors not assigned to clans
11
10212
22
1214
11
1511118
112
44
2125Families of metallopeptidases not assigned to clans
8194933477Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11361122Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1113Water nucleophile; water bound by single zinc ion ligated to His, Asp and His
5311111Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
2412211Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
1013587447Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
1181410236Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
2162112Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
6915223Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
22Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
221319Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
194515132816136Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
22113313254Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
112Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
1719Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
88172165910811454Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
4235840Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
23212212Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
224Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
3922723Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
615518540Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
747314879
134