Peptidases • Algae
Annotations/GenomesAplke1Araly1Astpho2Auran1Aurli1Auxeprot1Batpra1Bigna1Blahom1ChlNC64A_1Chlre4Chocri1Chrsp_1Chrzof1Coc_C169_1Crypto2293_1Cyamer1Dicre1Dunsal1Ectsil1Emihu1Fracy1Galsul1Giaint1Gonpec1Guith1MicpuC3v2MicpuN3v2Monneg1Naegr1Nangad1Nanoce1779_2Ochro2298_1Ost9901_3OstRCC809_2Ostta1115_2Ostta4221_3Oxytri1Partet1Pavlov2436_1Pelago2097_1Phaant1Phaglo1Phatr2Phyca11Phyci1Phyinf1Phypa1_1Phyra1_1Physo3Picsp_1Plafal1Poptr1_1Porumb1Psemu1Rapsub1Retfil1Sappar1SceoblEN4_1Schag1Selmo1Sobl393_1Sorbi1Symmic1SymretAf1SymretSc1SymretSp1SymretSw1Tetthe1Thaoce1Thaps3Toxgon1Trivag1Trybru1Volca1TotalAnnotation Description
Merops
34665327238433919315540516030928718225531527161113530628023362237019577277489176198358303228257404229102173166332677316358455357243523447370427458166872163272571,0535242983823661952982943052814702662927455312032522,827
11Families of aspartic peptidases not assigned to clans
355465221832361397831116879126125394542222741342321711439911236102741313229139911947105524861Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
111121119Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
57333325333322311424252243344445333284344476435216333323344432131523228Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
1111111112111115Water nucleophile; water bound by two Asp
11Water nucleophile; water bound by Asp and His; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
39662564541716622425291931212045172419235643182420451919325018284630101519731643540493526513341293615894014737520522720252329251342829511819262,558Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
315335121033215186525745113244111143323223332331462283475367676251764283Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
223311121321412223342541112117112344112019143181231612132331311114226Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
141111111123111111211121211113111145Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11111111111211116124Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
2529122312211131321122533213432233113321211111421211152222213152140Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Water nucleophile; water bound by Gln and Glu; all endopeptidases
31114Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
52057544686443562354669559342255833331127481287564105445755133943555578941336426Families of peptidase inhibitors not assigned to clans
1111417511011144
21115
55
521114124111121112154510322183
11316
2113111121112111122
612111111111122151185121113172
111115111114
11
123
1111211111111111111121
11215
13116
185121621151111131861115228951111721211121148
44
41212123221222213211211332222156
1113
112419
211112112121117
133113211253132411111312111213122131112211111121112221292Families of metallopeptidases not assigned to clans
23121122238417102444982511113615141029271114440982813121228848581917101918182516221217941317154245252233914151415331722416216881,531Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
8352522713417647348331144917222211331115112212234297346233214212235Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1113Water nucleophile; water bound by single zinc ion ligated to His, Asp and His
2236316211244211267671348111116910211153876921111331121431343333111232Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
131823121222341621334542422513242222424234422521632162232111123231174Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
716610766117756698868811119836105699599946510131081086101081010657787119778888876741248556Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
13211310115610581094111012412106996312105613898953851186149571098101331410720109111241213121110510222612634Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
74611558779644965211641544994956567624426654481087861545585676111112112231728421Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
653243324422232232322232153322112111124321311111132118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
112121121113219Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
6885534334354365447545513654563545354695455455445314545546445445362843318Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Water nucleophile; water bound by two cobalt ions ligated by Glu, Glu, His, His, Asp
11Water nucleophile; water bound by a metal ion but ligands unknown.
11Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
211111111312122211121111122112322221221122211111171Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
1764621237257681251148423033318877191213572462266101262438242938121233011820925739997121288752Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2534283323181627212518202225213026211829503327121926202227213030472291619194524342923292322252322181528302529472222291325212421283929162714191,769Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
41311548514289651110746124158817856910658534522111087548598843759121464143767613742717514Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1274261211341786662Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
21111221212212211221211121221112148Serine or threonine nucleophile; N-terminal nucleophile
1113Families of serine peptidases not assigned to clans
353868417413339657712181373111114615111111444107611562113566232540397666646175525Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
118218748787614411118767436649582115218974642139230968111505710084636584642750458817210287150103601441531271181694116288285105163918610359858484801085968118523645,903Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
71141129141341443327654232410612111216111525221862201Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
394325163434336356451057115242433833322345773334433226557546157652252223283Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
1111111111111Serine nucleophile; catalytic residues in the order His, Ser, His in sequence
111121222111112312113121111211121222112111121265Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
3171712310105121010101216319191092114911418912199111171310391111151712731231028161021133162181519167141018706Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1111111111111111111120Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
15118Serine nucleophile; catalytic residues in the order Lys, Ser in sequence
111115Serine nucleophile; catalytic residues in the order Ser, Glu, His
4208945662583177548689797106947159725661539841134536653106253441887784105527426Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2211414131222Families of peptidases of unknown catalytic mechanism not assigned to clans
213
112
2643529333214131493178134472413441013210682312148132593567472060302181212121010435816201554711464638512206111,710
11
11
1113111110
11
1111312111