Peptidases • Viridiplantae
Annotations/GenomesAraly1Astpho2Auxeprot1Batpra1ChlNC64A_1Chlre4Chrzof1Coc_C169_1Dicre1Dunsal1Gonpec1MicpuC3v2MicpuN3v2Monneg1Ost9901_3OstRCC809_2Ostta1115_2Ostta4221_3Phypa1_1Picsp_1Poptr1_1Rapsub1SceoblEN4_1Selmo1Sobl393_1Sorbi1SymretAf1SymretSc1SymretSp1SymretSw1Volca1TotalAnnotation Description
Merops
6532721931553092873152713062802771761983582291021731661662572983662982943052813257,310
55422239711121254222429991194173Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
73323323422334533323234443386Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11111211110Water nucleophile; water bound by two Asp
662517162529212024192019193230101519151420272523292526630Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
15313351654113111132456767499Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
231113412251111213233447Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
411111111111116Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11111121111113Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
52222211322332223312112222257Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2054464565453423333453455556131Families of peptidase inhibitors not assigned to clans
112
2114
55
52114111245128
211111112111115
6111110
1113
111111111111113
11
162111171122
44
41221231233222232
11
111115
3332251324312131211121122254Families of metallopeptidases not assigned to clans
121184244425111514449828848591525331415141588510Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
35223464343449222224742332293Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
2311142674111121111143433169Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
313122411322252222231111150Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
1666675988865699465689788888199Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
211356810111012101256135385379121213121112254Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
46589696116949562446557111112118189Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
65323344233223332222311111269Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
112111213215Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
883443364735455354344445443119Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
211111312111121112221111133Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
64232571258487719724612119799978217Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
34281816251825212118192022272291619182522292521242119582Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
131185891110612756953454961476767203Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
42211786637Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
111111118Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
53841133967733111111126253966665234Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
2187461447674958289746850571006427504541859110385848480642,065Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1121133111222122Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
945143366412423332355657653110Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111111111110Serine nucleophile; catalytic residues in the order His, Ser, His in sequence
11122112311312211111231Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
17171010121012161910118912117131010101316181519168339Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
111111118Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
15118Serine nucleophile; catalytic residues in the order Lys, Ser in sequence
2085658778676947256663488777182Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
1449Families of peptidases of unknown catalytic mechanism not assigned to clans
43313147872410231293564151646311174
33
11
123