Peptidases • Excavata
Annotations/GenomesGiaint1Naegr1Trivag1Trybru1TotalAnnotation Description
Merops
773035531201,053
1326Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
527Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
245011819211Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
217625Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
111113Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
112Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1168Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
156Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
213318Families of peptidase inhibitors not assigned to clans
21214
134
516
11
22
118221
11
1113Families of metallopeptidases not assigned to clans
11316216192Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
134Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
3912428Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
3822639Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
67215Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
168419Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
11213Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
1221271474Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
1107119Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
22Serine or threonine nucleophile; N-terminal nucleophile
111719Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
9848523201Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
224Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
14229Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
112Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
75214Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
21420642
11
11