Peptidases • Heterokonta
Annotations/GenomesAplke1Auran1Aurli1Blahom1Ectsil1Fracy1Nangad1Nanoce1779_2Ochro2298_1Pelago2097_1Phatr2Phyca11Phyci1Phyinf1Phyra1_1Physo3Psemu1Sappar1Schag1Thaoce1Thaps3TotalAnnotation Description
Merops
3463843391602333702282574043582435234473704274583275243822662927,338
36536794547114399112367132105406Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
12115Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
53334544434764353331380Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11114Water nucleophile; water bound by two Asp
11Water nucleophile; water bound by Asp and His; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
396454242343182846402651334129364075522829819Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
33510274422333236372579Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
231342117412019143183131120Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111131112113Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1113Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
2911123433121114211346Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
57586955887564105713989149Families of peptidase inhibitors not assigned to clans
1141751101141
325
11316
3115
2111151185121149
112
112
112
11
1851162511112237
2221119
11
21216
11111112131221120Families of metallopeptidases not assigned to clans
232223101027121228101825162212171745221722410Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
8251371112213934255Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
263261691072113133369Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
18213532444422523623268Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
7107711959986101081010711767174Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
13101156998914710981013101011510197Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
71157445676481087848623130Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
232152111131326Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
65535535444554455563697Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Water nucleophile; water bound by two cobalt ions ligated by Glu, Glu, His, His, Asp
11Water nucleophile; water bound by a metal ion but ligands unknown.
1121222122117Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
176212331356624382429383020252128377Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
253323212933303047342923222523223047223929616Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
4542486588485988514474130Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
21212111221218Serine or threonine nucleophile; N-terminal nucleophile
36841846154107611565234046182Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
11887871864926365848760144153127118169821638659681,994Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
7411476541212115676Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
33235533853334436742584Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111112112111212120Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
3123914991111127312316131410153Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
111111118Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
111115Serine nucleophile; catalytic residues in the order Ser, Glu, His
494287159911345361054410123Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
213Families of peptidases of unknown catalytic mechanism not assigned to clans
112
26352914131081325608121212101081547512384
11114