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PFAM Domains • Apicomplexa
Annotations/GenomesPlafal1Toxgon1TotalAnnotation Description
343872ATPase family associated with various cellular activities (AAA)
162440ABC transporter
448ATP synthase alpha/beta family, nucleotide-binding domain
33EGF-like domain
222143Elongation factor Tu GTP binding domain
369Hsp20/alpha crystallin family
6713Hsp70 protein
6915KH domain
268Ankyrin repeat
1616PAN domain
8816ADP-ribosylation factor family
10616Eukaryotic aspartyl protease
279Cyclic nucleotide-binding domain
33Cytochrome b(C-terminal)/b6/petD
224Cytochrome c
1124Fe-4S binding domain
112Glutathione S-transferase, C-terminal domain
123Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
66Kazal-type serine protease inhibitor domain
112Kringle domain
336lactate/malate dehydrogenase, NAD binding domain
11Lectin C-type domain
61117Myosin head (motor domain)
33LNR domain
11Cytochrome P450
85132217Protein kinase domain
8917Pyridine nucleotide-disulphide oxidoreductase
141933Ras family
11Response regulator receiver domain
11RNase H
5672128RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
22Serpin (serine protease inhibitor)
235Iron/manganese superoxide dismutases, alpha-hairpin domain
31215Subtilase family
257Sugar (and other) transporter
123Sushi repeat (SCR repeat)
6511Thrombospondin type 1 domain
6915Tubulin/FtsZ family, GTPase domain
426von Willebrand factor type A domain
112Zinc finger, C2H2 type
123Zinc finger, C3HC4 type (RING finger)
33Zinc knuckle
41317short chain dehydrogenase
33Zinc-binding dehydrogenase
123Thiolase, N-terminal domain
156Beta-ketoacyl synthase, N-terminal domain
2352Fe-2S iron-sulfur cluster binding domain
16521Papain family cysteine protease
123Enolase, C-terminal TIM barrel domain
11Cytochrome C and Quinol oxidase polypeptide I
112Cytochrome C oxidase subunit II, periplasmic domain
448Glutamine amidotransferase class-I
101121TCP-1/cpn60 chaperonin family
112Glutamine synthetase, catalytic domain
224Triosephosphate isomerase
121830E1-E2 ATPase
81018Core histone H2A/H2B/H3/H4
44Alpha amylase, catalytic domain
11Phorbol esters/diacylglycerol binding domain (C1 domain)
538Bacterial transferase hexapeptide (six repeats)
6713tRNA synthetases class I (I, L, M and V)
459Cyclin, N-terminal domain
347DNA polymerase family B
336ATP synthase subunit C
123C-5 cytosine-specific DNA methylase
151934Calcineurin-like phosphoesterase
6410tRNA synthetases class II (D, K and N)
142135Mitochondrial carrier protein
3710Aminotransferase class I and II
224Phosphoribosyl transferase domain
111526Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
123Phosphoglycerate kinase
123Ribosomal protein S4/S9 N-terminal domain
336Ribosomal protein S12/S23
224Chaperonin 10 Kd subunit
21012C2 domain
6511PH domain
11bZIP transcription factor
66Aldehyde dehydrogenase family
3710Cytochrome b5-like Heme/Steroid binding domain
11Oxidoreductase molybdopterin binding domain
347Oxidoreductase NAD-binding domain
111829SNF2 family N-terminal domain
224Ribosomal protein S7p/S5e
151732Ubiquitin-conjugating enzyme
123Isocitrate/isopropylmalate dehydrogenase
336Ribosomal Proteins L2, RNA binding domain
11Chitinase class I
448Hsp90 protein
112Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
112Dihydrofolate reductase
145Cysteine-rich secretory protein family
224Ribosomal protein S3, C-terminal domain
123Eukaryotic-type carbonic anhydrase
3362-oxoacid dehydrogenases acyltransferase (catalytic domain)
112Aminotransferase class-III
224Ribosomal protein S19
224DNA gyrase B
325Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
257Sodium:neurotransmitter symporter family
6511Adenylate and Guanylate cyclase catalytic domain
112ATP synthase delta (OSCP) subunit
112Orotidine 5'-phosphate decarboxylase / HUMPS family
112Bacterial DNA-binding protein
33ATP:guanido phosphotransferase, C-terminal catalytic domain
112Indole-3-glycerol phosphate synthase
11Aromatic amino acid lyase
224Pyruvate kinase, barrel domain
92029Kinesin motor domain
453681DnaJ domain
151530Proteasome subunit
224Major intrinsic protein
112ATP synthase
618243'5'-cyclic nucleotide phosphodiesterase
325Ribosomal protein L22p/L17e
336Ribosomal protein L14p/L23e
131427Ubiquitin family
213Cofilin/tropomyosin-type actin-binding protein
34714-3-3 protein
145Zinc carboxypeptidase
246Aldo/keto reductase family
167Myb-like DNA-binding domain
336Ribosomal protein L16p/L10e
213Ribosomal protein S14p/S29e
257FKBP-type peptidyl-prolyl cis-trans isomerase
123Glutathione peroxidase
11Calreticulin family
2810Aminotransferase class-V
213Ribonucleotide reductase, small chain
5158109DEAD/DEAH box helicase
6377140Helicase conserved C-terminal domain
134Fructose-bisphosphate aldolase class-I
11EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
224Ribosomal protein L23
112Pyridoxal-dependent decarboxylase, C-terminal sheet domain
112Ribosomal protein L5
11Pyridoxal-dependent decarboxylase conserved domain
246Citrate synthase, C-terminal domain
22GHMP kinases N terminal domain
246Biotin carboxylase, N-terminal domain
33Pyridoxal-phosphate dependent enzyme
347NUDIX domain
22pfkB family carbohydrate kinase
336Ribosomal protein L3
224Ribosomal protein L11, RNA binding domain
31013Histidine phosphatase superfamily (branch 1)
112Thymidylate synthase
448ATP synthase alpha/beta chain, C terminal domain
22Calponin homology (CH) domain
11Glutamine amidotransferases class-II
11Phosphoenolpyruvate carboxylase
336Ribosomal protein S15
123'Cold-shock' DNA-binding domain
33Fructose-1-6-bisphosphatase, N-terminal domain
112Ribonucleotide reductase, all-alpha domain
224Ribosomal protein S2
11GATA zinc finger
145Prolyl oligopeptidase family
112Ribosomal protein L30p/L7e
123Histidine phosphatase superfamily (branch 2)
112Aconitase family (aconitate hydratase)
11Glycosyl hydrolases family 17
235Ribosomal protein S5, N-terminal domain
235Nucleoside diphosphate kinase
325Ribosomal protein S10p/S20e
11Arrestin (or S-antigen), N-terminal domain
112Phosphoglucose isomerase
11Carbohydrate phosphorylase
112SecY translocase
112Ribosomal protein L6
224Polyprenyl synthetase
549Dynamin family
33Biopterin-dependent aromatic amino acid hydroxylase
325Transcription factor TFIID (or TATA-binding protein, TBP)
235Rieske [2Fe-2S] domain
4812Biotin-requiring enzyme
224Ribosomal protein S17
11FGGY family of carbohydrate kinases, N-terminal domain
268Enoyl-CoA hydratase/isomerase
336Ribosomal protein S9/S16
224Transcription factor TFIIB repeat
246Cytidine and deoxycytidylate deaminase zinc-binding region
336Chromo (CHRromatin Organisation MOdifier) domain
112Phosphatidylinositol-specific phospholipase C, Y domain
112Phosphatidylinositol-specific phospholipase C, X domain
11D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1236-phosphogluconate dehydrogenase, C-terminal domain
5813WW domain
224Ribosomal RNA adenine dimethylase
6292154WD domain, G-beta repeat
22Heavy-metal-associated domain
4913Adenylate kinase
235Phosphoglucomutase/phosphomannomutase, C-terminal domain
224Ribosomal protein S8
325Ribosomal protein S11
61521Regulator of chromosome condensation (RCC1) repeat
112Ribosomal protein S13/S18
112chorismate binding enzyme
33660s Acidic ribosomal protein
123Prenyltransferase and squalene oxidase repeat
11Protein kinase C terminal domain
112Single-strand binding protein family
112S-adenosylmethionine synthetase, N-terminal domain
33Acyl-CoA dehydrogenase, C-terminal domain
81523Ubiquitin carboxyl-terminal hydrolase
112Ribosomal protein L36
224SRP54-type protein, GTPase domain
112Ribosomal protein L20
3912Phosphatidylinositol 3- and 4-kinase
112Transketolase, thiamine diphosphate binding domain
33Inositol monophosphatase family
213Serine hydroxymethyltransferase
325Ribosomal protein L10
437KOW motif
224Ribosomal protein L33
6410RF-1 domain
11Sodium:solute symporter family
224DNA polymerase family A
112IMP dehydrogenase / GMP reductase domain
123Glucose-6-phosphate dehydrogenase, NAD binding domain
92938Protein phosphatase 2C
112Nucleotidyl transferase
123Fatty acid desaturase
437MutS domain V
112Delta-aminolevulinic acid dehydratase
11Arginase family
8816MCM P-loop domain
5914FHA domain
141226AMP-binding enzyme
347HMG (high mobility group) box
11Cytochrome c oxidase subunit III
145Armadillo/beta-catenin-like repeat
7815Tetratricopeptide repeat
66Ion transport protein
224DNA gyrase/topoisomerase IV, subunit A
123Scavenger receptor cysteine-rich domain
257BRCA1 C Terminus (BRCT) domain
156Glycosyl transferases group 1
189Glycosyl transferase family 2
224Ribosomal protein L7/L12 C-terminal domain
156Phosphopantetheine attachment site
112Formyl transferase
7815Metallopeptidase family M24
123Leucine Rich Repeat
11alpha/beta hydrolase fold
448RNA polymerase Rpb2, domain 6
134Staphylococcal nuclease homologue
101727Rab-GTPase-TBC domain
123Tudor domain
145Zinc finger, ZZ type
112HRDC domain
134CBS domain
224Ribosomal protein L13
336Ribosomal protein L4/L1 family
235Clp protease
4711S1 RNA binding domain
437AhpC/TSA family
448tRNA synthetases class I (W and Y)
112UvrD/REP helicase N-terminal domain
235Rhodanese-like domain
11Universal stress protein family
61218Acetyltransferase (GNAT) family
112SecE/Sec61-gamma subunits of protein translocation complex
112AIR synthase related protein, N-terminal domain
6814tRNA synthetase class II core domain (G, H, P, S and T)
448SpoU rRNA Methylase family
112Phage integrase family
112Tetrapyrrole (Corrin/Porphyrin) Methylases
11PDZ domain
235Diacylglycerol kinase accessory domain
11Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
11Fes/CIP4, and EFC/F-BAR homology domain
4610IQ calmodulin-binding motif
123Phosphoinositide 3-kinase family, accessory domain (PIK domain)
11Phospholipase D Active site motif
112RhoGAP domain
336SPRY domain
448RNA polymerase Rpb1, domain 2
112Guanylate kinase
224Gelsolin repeat
5914UBA/TS-N domain
11MAM domain, meprin/A5/mu
336Filamin/ABP280 repeat
3912HECT-domain (ubiquitin-transferase)
123Helix-hairpin-helix motif
112MSP (Major sperm protein) domain
11Ribonuclease III domain
123Region in Clathrin and VPS
112RanBP1 domain
22PPIC-type PPIASE domain
246Zn-finger in Ran binding protein and others
52328Zinc finger C-x8-C-x5-C-x3-H type (and similar)
246B-box zinc finger
22Poly(ADP-ribose) polymerase catalytic domain
134Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
213F-box domain
112Elongation factor 1 gamma, conserved domain
112Calpain family cysteine protease
41014CRAL/TRIO domain
88BTB/POZ domain
156Ricin-type beta-trefoil lectin domain
22Voltage gated chloride channel
235Caspase domain
112Poly-adenylate binding protein, unique domain
91120ABC transporter transmembrane region
22FAD binding domain
123S-adenosyl-L-homocysteine hydrolase, NAD binding domain
112ribosomal L5P family C-terminus
6915Insulinase (Peptidase family M16)
347Dehydrogenase E1 component
8816Elongation factor G C-terminus
235DnaJ central domain
55Starch binding domain
347Ribosomal protein L1p/L10e family
246Cation transporting ATPase, C-terminus
268Cation transporter/ATPase, N-terminus
112Aconitase C-terminal domain
22Amino acid kinase family
145Acyl transferase domain
11Dihydrodipicolinate synthetase family
41014haloacid dehalogenase-like hydrolase
11Glycosyl hydrolases family 18
224Proliferating cell nuclear antigen, N-terminal domain
112Translation initiation factor IF-3, C-terminal domain
112Adenylosuccinate synthetase
11Asparaginase, N-terminal
123Peptidase S24-like
213Inorganic pyrophosphatase
11Glycosyl hydrolases family 16
113-hydroxyacyl-CoA dehydrogenase, C-terminal domain
336HhH-GPD superfamily base excision DNA repair protein
66GMC oxidoreductase
224Asparagine synthase
224EF-1 guanine nucleotide exchange domain
336tRNA synthetases class I (E and Q), catalytic domain
224tRNA synthetases class I (R)
358XPG N-terminal domain
246Metallo-beta-lactamase superfamily
268F5/8 type C domain
112Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
11Electron transfer flavoprotein FAD-binding domain
336RNB domain
11DIX domain
11CNH domain
235Diacylglycerol kinase catalytic domain
3811Dual specificity phosphatase, catalytic domain
11MyTH4 domain
235PX domain
235UBX domain
22Carbon-nitrogen hydrolase
11Pentapeptide repeats (8 copies)
224Pumilio-family RNA binding repeat
415Histone-like transcription factor (CBF/NF-Y) and archaeal histone
112Pterin binding enzyme
369ER lumen protein retaining receptor
325Glycoprotease family
134impB/mucB/samB family
112Ribosomal L15
437Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
224Ribosomal prokaryotic L21 protein
224Ribosomal L28 family
123Ribosomal L29 protein
112Ribosomal L39 protein
112Ribosomal S17
112Ribulose-phosphate 3 epimerase family
112Translationally controlled tumour protein
234467AP2 domain
5914RNA pseudouridylate synthase
358Histone deacetylase domain
11PWWP domain
81523SET domain
112Isochorismatase family
224Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
5510XPG I-region
112DNA photolyase
112Cytosol aminopeptidase family, catalytic domain
112Ribosomal protein S16
527Acyl CoA binding protein
246Cullin family
123Elongation factor TS
123FAD binding domain
314EamA-like transporter family
8816ThiF family
112Ribosomal family S4e
123Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
145Sulfate permease family
11MATH domain
112Uncharacterized protein family UPF0004
11Transaldolase/Fructose-6-phosphate aldolase
123Mechanosensitive ion channel
5611Adaptor complexes medium subunit family
11Dipeptidyl peptidase IV (DPP IV) N-terminal region
112Ribosomal protein L44
11Sodium:sulfate symporter transmembrane region
112DNA-dependent RNA polymerase
112Glycosyl transferase family 4
235Nucleosome assembly protein (NAP)
112GMP synthase C terminal domain
235Adenosine/AMP deaminase
224Oxidoreductase FAD-binding domain
11Glycosyltransferase family 20
11Merozoite Surface Antigen 2 (MSA-2) family
11DNA gyrase B subunit, carboxyl terminus
112Carbamoyl-phosphate synthase small chain, CPSase domain
11Probable molybdopterin binding domain
448Sec1 family
224GDP dissociation inhibitor
145Sodium/hydrogen exchanger family
437RNA polymerase Rpb3/RpoA insert domain
11Inward rectifier potassium channel transmembrane domain
347Initiation factor 2 subunit family
22Electron transfer flavoprotein domain
112Ribosomal S3Ae family
213Ribosomal L27 protein
112Ribosomal L40e family
112TatD related DNase
246Inhibitor of apoptosis-promoting Bax1
112Eukaryotic DNA topoisomerase I, catalytic core
235Dynamin central region
134Carboxyl transferase domain
224UbiA prenyltransferase family
11Endoribonuclease L-PSP
134Phosphorylase superfamily
11Cys/Met metabolism PLP-dependent enzyme
11Glycosyl hydrolases family 31
167ABC-2 type transporter
22Bestrophin, RFP-TM, chloride channel
123Amino-transferase class IV
257CDP-alcohol phosphatidyltransferase
112Calpain large subunit, domain III
123ATP dependent DNA ligase domain
112Ribosomal protein S18
112Clathrin light chain
224Ubiquitin carboxyl-terminal hydrolase, family 1
112Ribosomal protein S19e
112Ribosomal protein S6e
347Transcription factor S-II (TFIIS)
11Surface antigen
448emp24/gp25L/p24 family/GOLD
224NifU-like domain
246Cyclin-dependent kinase regulatory subunit
11Dihydrodipicolinate reductase, N-terminus
112F-actin capping protein, beta subunit
11Semialdehyde dehydrogenase, NAD binding domain
224DNA mismatch repair protein, C-terminal domain
11Dephospho-CoA kinase
11MAPEG family
112G10 protein
11Heme oxygenase
1122-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
134DNA topoisomerase
112Elongation factor P (EF-P) OB domain
112Enhancer of rudimentary
112Glucose inhibited division protein A
112Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
112RNA 3'-terminal phosphate cyclase
46103' exoribonuclease family, domain 1
213tRNA-splicing ligase RtcB
224tRNA pseudouridine synthase D (TruD)
347SPFH domain / Band 7 family
325Cytidylyltransferase family
2810GDA1/CD39 (nucleoside phosphatase) family
336GNS1/SUR4 family
112Ribosomal protein L21e
112Ribosomal protein L36e
112Ribosomal protein L6e
224Phosphatidylethanolamine-binding protein
224RIO1 family
112Tub family
112Alanine racemase, N-terminal domain
22Uncharacterized protein family UPF0016
134Putative RNA methylase family UPF0020
235PP-loop family
112Shwachman-Bodian-Diamond syndrome (SBDS) protein
213SNO glutamine amidotransferase family
224Translation initiation factor 1A / IF-1
11Copper amine oxidase, enzyme domain
112Dihydroorotate dehydrogenase
112Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
112Macrophage migration inhibitory factor (MIF)
581316S rRNA methyltransferase RsmB/F
112RNA polymerase Rpb5, C-terminal domain
112RNA polymerase Rpb6
448RNA polymerase Rpb3/Rpb11 dimerisation domain
112RNA polymerases N / 8 kDa subunit
11Peptidyl-tRNA hydrolase
224Ribosomal protein L17
112Ribosomal protein L31e
112Ribosomal protein L34e
112Ribosomal protein S28e
224Ribosomal protein S8e
11Shikimate kinase
11Uncharacterized protein family UPF0029
257Dihydrouridine synthase (Dus)
112Uroporphyrinogen decarboxylase (URO-D)
112ubiE/COQ5 methyltransferase family
224NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
224Casein kinase II regulatory subunit
112Cytochrome c oxidase subunit Vb
7714Clathrin adaptor complex small chain
112Coproporphyrinogen III oxidase
4610Dynein light chain type 1
11DNA/RNA non-specific endonuclease
134Formate/nitrite transporter
112GTP cyclohydrolase I
235HIT domain
112Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
134Oxysterol-binding protein
112Phosphomannose isomerase type I
22Protein prenyltransferase alpha subunit repeat
1126-pyruvoyl tetrahydropterin synthase
112Ribosomal protein L19
224Ribosomal protein L24e
112Ribosomal protein L35Ae
6612Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
112Ribosomal protein S21e
224Ribosomal protein S6
112Ribosomal protein S7e
347Translation initiation factor SUI1
112Putative undecaprenyl diphosphate synthase
112Carbohydrate kinase
112Xylose isomerase-like TIM barrel
145Alanine dehydrogenase/PNT, C-terminal domain
112Chorismate synthase
224Cytochrome c/c1 heme lyase
123FAD dependent oxidoreductase
112F-actin capping protein alpha subunit
112Orn/Lys/Arg decarboxylase, major domain
112Ribosomal protein L19e
213Ribosomal protein L9, N-terminal domain
112Ribosomal protein S24e
112Ribosomal protein S26e
112Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
1127,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
123Phosphoenolpyruvate carboxykinase
112Ribosomal protein L13e
112Telomere recombination
112Glycosyl hydrolases family 35
235CAP-Gly domain
112Creatinase/Prolidase N-terminal domain
22Pyruvate phosphate dikinase, PEP/pyruvate binding domain
112Polypeptide deformylase
112Pterin 4 alpha carbinolamine dehydratase
112mRNA capping enzyme, catalytic domain
8614OB-fold nucleic acid binding domain
347Kelch motif
11Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
112Ribonuclease HII
224FYVE zinc finger
115'-3' exonuclease, C-terminal SAM fold
112DHH family
145Sec7 domain
246NAD dependent epimerase/dehydratase family
112Porphobilinogen deaminase, dipyromethane cofactor binding domain
112SIS domain
112Phosphate transporter family
112ARID/BRIGHT DNA binding domain
11Collagen triple helix repeat (20 copies)
11Clathrin propeller repeat
22Topoisomerase DNA binding C4 zinc finger
369JAB1/Mov34/MPN/PAD-1 ubiquitin protease
91019PCI domain
314tRNA synthetases class I (C) catalytic domain
11Oxidoreductase family, NAD-binding Rossmann fold
325tRNA synthetases class II core domain (F)
112tRNA synthetases class II (A)
437Putative GTPase activating protein for Arf
336tRNA pseudouridine synthase
112ENTH domain
151530LSM domain
11R3H domain
246AN1-like Zinc finger
11Peptidase family M13
235Peptidase family M3
246Peptidase family M1 domain
336Peptidase family M41
11Peptidase family M48
11Viral (Superfamily 1) RNA helicase
11ELM2 domain
224Uncharacterized protein family (UPF0051)
224Eukaryotic porin
11GRIP domain
112Skp1 family, dimerisation domain
11Pyroglutamyl peptidase
246PUA domain
11Class-II DAHP synthetase family
11LysM domain
123PLAT/LH2 domain
5510S4 domain
224PWI domain
112IBR domain, a half RING-finger domain
11Type I 3-dehydroquinase
156Transmembrane amino acid transporter protein
11Frataxin-like domain
11GXGXG motif
123FAD binding domain
123V-type ATPase 116kDa subunit family
11Glycosyl transferase family 8
134Phosphatidylinositol-4-phosphate 5-Kinase
112Phosphoadenosine phosphosulfate reductase family
224TruB family pseudouridylate synthase (N terminal domain)
11ATP-NAD kinase
325Iron-sulphur cluster biosynthesis
121830DHHC palmitoyltransferase
134PPR repeat
11Adenosylmethionine decarboxylase
11GIY-YIG catalytic domain
22CorA-like Mg2+ transporter protein
112Cation efflux family
11Peptidase family M20/M25/M40
8513DnaJ C terminal domain
11Spermine/spermidine synthase domain
112Natural resistance-associated macrophage protein
112PAP2 superfamily
224Aminomethyltransferase folate-binding domain
11MaoC like domain
11Adenylylsulphate kinase
235G-patch domain
123Putative tRNA binding domain
33GAF domain
112NifU-like N terminal domain
325Flavin containing amine oxidoreductase
123Cyclin M transmembrane N-terminal domain
112Glycine cleavage H-protein
112Ribosomal protein S27a
91019Adaptin N terminal region
11Protein phosphatase 2A regulatory B subunit (B56 family)
55103'-5' exonuclease
11Proline dehydrogenase
224MutS domain I
11Peptide methionine sulfoxide reductase
112Ribosomal protein L35
235Choline/ethanolamine kinase
11ATPase domain predominantly from Archaea
11SelR domain
11Conserved region in glutamate synthase
1234'-phosphopantetheinyl transferase superfamily
112Peptidase C13 family
235Eukaryotic initiation factor 4E
11NAD-dependent DNA ligase adenylation domain
112Ribosomal protein L32
11Myo-inositol-1-phosphate synthase
336Macro domain
112Ribosomal protein S27
112SOR/SNZ family
112Riboflavin kinase
9615Rhomboid family
112Sodium/calcium exchanger protein
336Queuine tRNA-ribosyltransferase
123UTP--glucose-1-phosphate uridylyltransferase
112IPP transferase
123BolA-like protein
112Ham1 family
4711FtsJ-like methyltransferase
33Nucleoside transporter
347Patatin-like phospholipase
22STAS domain
112Poly A polymerase head domain
123tRNA (Guanine-1)-methyltransferase
112Importin beta binding domain
358Toprim domain
3710MYND finger
112A20-like zinc finger
11Acyl-CoA oxidase
113-dehydroquinate synthase
145Lipase (class 3)
224Ribosome recycling factor
112Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
112Ribosomal L22e protein family
112Ribosomal L27e protein family
224Ribosomal L28e protein family
112Ribosomal L29e protein family
224Ribosomal L37ae protein family
112Ribosomal L38e protein family
112RimM N-terminal domain
123DeoC/LacD family aldolase
112MraW methylase family
336snoRNA binding domain, fibrillarin
11Penicillin amidase
235Surp module
1125-formyltetrahydrofolate cyclo-ligase family
112ATP synthase subunit D
527MAC/Perforin domain
11IPT/TIG domain
22ACT domain
112HNH endonuclease
224FF domain
224NAC domain
112Proteasome/cyclosome repeat
156START domain
123MOZ/SAS family
224Putative diphthamide synthesis protein
112Domain of unknown function UPF0086
224Domain found in IF2B/IF5
112Memo-like protein
112RNase P subunit p30
213Iron-sulfur cluster assembly protein
22RNA 2'-phosphotransferase, Tpt1 / KptA family
11Uncharacterised protein family UPF0047
112DNA primase small subunit
11Rpp14/Pop5 family
112Diphthamide synthase
11Putative heavy-metal-binding
112Ribosomal protein L37e
325Nucleotidyltransferase domain
112eIF-6 family
112Deoxyhypusine synthase
549Prefoldin subunit
112SRP19 protein
33Sulfite exporter TauE/SafE
20214150S ribosome-binding GTPase
112Ribosomal protein L14
112Protein of unknown function DUF89
112Archease protein family (MTH1598/TM1083)
224Integral membrane protein EMC3/TMCO1-like
112DJ-1/PfpI family
112HD domain
11MoaC family
224tRNA intron endonuclease, catalytic C-terminal domain
224Peptidyl-tRNA hydrolase PTH2
11Double-stranded DNA-binding domain
112VIT family
112ATP synthase (F/14-kDa) subunit
112ATP synthase (E/31 kDa) subunit
112ATP synthase (C/AC39) subunit
11Translin family
11TFIIE alpha subunit
112N2,N2-dimethylguanosine tRNA methyltransferase
11REJ domain
224Ribosome-binding factor A
11SCP-2 sterol transfer family
134SAP domain
11CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
11260Kd inner membrane protein
112SURF1 family
112DAD family
11Hydroxyethylthiazole kinase family
112Phosphatidylinositol transfer protein
112Aminopeptidase I zinc metalloprotease (M18)
11X-Pro dipeptidyl-peptidase (S15 family)
112Uncharacterized protein family UPF0054
123Nuclear transport factor 2 (NTF2) domain
11Adenosine-deaminase (editase) domain
112Beige/BEACH domain
112Galactose binding lectin domain
112MGS-like domain
11Repair protein Rad1/Rec1/Rad17
224Sir2 family
336Zn-finger in ubiquitin-hydrolases and other protein
123RNA polymerases M/15 Kd subunit
112Peptidase family M50
112Cytochrome C1 family
11Piwi domain
11TRAF-type zinc finger
11AT hook motif
235Formin Homology 2 Domain
11SAD/SRA domain
11HAT (Half-A-TPR) repeat
112ATP-dependent protease La (LON) substrate-binding domain
22Regulatory subunit of type II PKA R-subunit
224SWIB/MDM2 domain
224Vacuolar sorting protein 9 (VPS9) domain
123Putative zinc finger in N-recognin (UBR box)
224Dynamin GTPase effector domain
347GYF domain
235BTB/POZ domain
11ML domain
112Thymidylate kinase
22PA domain
123NAD(P) transhydrogenase beta subunit
11Methylpurine-DNA glycosylase (MPG)
123Proteasome activator pa28 beta subunit
22FAT domain
33FATC domain
123Guanylate-binding protein, N-terminal domain
336S1/P1 Nuclease
112TFIIF, beta subunit HTH domain
112Ubiquinol-cytochrome C reductase complex 14kD subunit
112Signal recognition particle 14kD protein
11Alpha adaptin AP2, C-terminal domain
22Cytochrome oxidase c subunit VIb
224HORMA domain
11NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
112Ubiquinol-cytochrome C reductase hinge protein
112YGGT family
112Mitochondrial glycoprotein
41620OTU-like cysteine protease
22TerD domain
246Cell division protein 48 (CDC48), N-terminal domain
11Cysteine rich repeat
111,3-beta-glucan synthase component
123JmjC domain, hydroxylase
213Anion-transporting ATPase
347SacI homology domain
11Cornifin (SPRR) family
112Putative methyltransferase
11MoaE protein
112LytB protein
112Seryl-tRNA synthetase N-terminal domain
123Ribosomal silencing factor during starvation
11Ferrous iron transport protein B
336Apical membrane antigen 1
11Conserved carboxylase domain
112Lecithin:cholesterol acyltransferase
167Patched family
459RecF/RecN/SMC N terminal domain
336Tim17/Tim22/Tim23/Pmp24 family
123Fasciclin domain
336Met-10+ like-protein
112CobW/HypB/UreG, nucleotide-binding domain
91625MORN repeat
112Oligosaccharyl transferase STT3 subunit
134CPBP intramembrane metalloprotease
4610Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
33Glycophorin-binding protein
246ZIP Zinc transporter
11CrcB-like protein, Camphor Resistance (CrcB)
224NAD synthase
112YgbB family
2353-oxo-5-alpha-steroid 4-dehydrogenase
224Maf-like protein
11Ketopantoate hydroxymethyltransferase
11Ketopantoate reductase PanE/ApbA
11Pantoate-beta-alanine ligase
112Homocysteine S-methyltransferase
11RimP N-terminal domain
112D-Tyr-tRNA(Tyr) deacylase
11Thiamine monophosphate synthase
325Uncharacterised ACR, YagE family COG1723
112GlcNAc-PI de-N-acetylase
213SOS response associated peptidase (SRAP)
112Uncharacterised ACR, YggU family COG1872
112Putative RNA methyltransferase
112ATP-dependent Clp protease adaptor protein ClpS
112Uncharacterized ACR, COG1678
112Cytochrome oxidase assembly protein
123CoA binding domain
112GatB domain
11Uncharacterized ACR, COG1430
22Domain of unknown function (DUF202)
112Fe-S metabolism associated domain
123Phosphatidylserine decarboxylase
1121-deoxy-D-xylulose 5-phosphate reductoisomerase
123Methyltransferase TYW3
33N-terminal domain of galactosyltransferase
112Calcium-dependent channel, 7TM region, putative phosphate
112Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
112SKIP/SNW domain
325ERCC4 domain
22Ku70/Ku80 beta-barrel domain
113-hydroxyacyl-CoA dehydrogenase, NAD binding domain
1125'-3' exonuclease, N-terminal resolvase-like domain
224Proliferating cell nuclear antigen, C-terminal domain
11Transcription initiation factor IIA, gamma subunit
11Arrestin (or S-antigen), C-terminal domain
112AIR synthase related protein, C-terminal domain
55Acyl-CoA dehydrogenase, middle domain
33Acyl-CoA dehydrogenase, N-terminal domain
112S-adenosylmethionine synthetase, central domain
112S-adenosylmethionine synthetase, C-terminal domain
11Semialdehyde dehydrogenase, dimerisation domain
11Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
11Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
235Iron/manganese superoxide dismutases, C-terminal domain
5510Transketolase, pyrimidine binding domain
347Transketolase, C-terminal domain
123Glucose-6-phosphate dehydrogenase, C-terminal domain
11FGGY family of carbohydrate kinases, C-terminal domain
112Pyridoxal-dependent decarboxylase, pyridoxal binding domain
134Biotin carboxylase C-terminal domain
246Carbamoyl-phosphate synthase L chain, ATP binding domain
112Carbamoyl-phosphate synthetase large chain, oligomerisation domain
11Cytosol aminopeptidase family, N-terminal domain
112Cytochrome C oxidase subunit II, transmembrane domain
112Mago nashi protein
11Glutathione S-transferase, N-terminal domain
112Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
123Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
156Beta-ketoacyl synthase, C-terminal domain
123Thiolase, C-terminal domain
33Alpha amylase, C-terminal all-beta domain
11Ubiquitin interaction motif
112SEC-C motif
213Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
22e3 binding domain
112ATP synthase, Delta/Epsilon chain, beta-sandwich domain
224TGS domain
11WWE domain
22D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
11DHHA2 domain
112Prp18 domain
11Guanylate-binding protein, C-terminal domain
224MA3 domain
6511Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
55MIF4G domain
246Clp amino terminal domain, pathogenicity island component
112DDHD domain
336lactate/malate dehydrogenase, alpha/beta C-terminal domain
112Ribonucleotide reductase, barrel domain
225'-nucleotidase, C-terminal domain
448ATP synthase alpha/beta family, beta-barrel domain
11Poly(ADP-ribose) polymerase, regulatory domain
235Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
123Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
123Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
213SRP54-type protein, helical bundle domain
112Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
123Adaptin C-terminal domain
224Pyruvate kinase, alpha/beta domain
336Sec63 Brl domain
123MIZ/SP-RING zinc finger
112GRAM domain
11Prolyl oligopeptidase, N-terminal beta-propeller domain
134Ulp1 protease family, C-terminal catalytic domain
112Iron only hydrogenase large subunit, C-terminal domain
112Fumarate reductase flavoprotein C-term
11Formyl transferase, C-terminal domain
112Eukaryotic DNA topoisomerase I, DNA binding fragment
112Ubiquinol cytochrome reductase transmembrane region
22Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
11C5HC2 zinc finger
11Neurotransmitter-gated ion-channel transmembrane region
213Cell division protein 48 (CDC48), domain 2
112GatB/GatE catalytic domain
112mRNA capping enzyme, beta chain
5510Tim10/DDP family zinc finger
112Mitosis protein DIM1
112Tubulin binding cofactor A
112Signal peptide binding domain
112Cyclin, C-terminal domain
22HEAT repeat
123Endomembrane protein 70
112Autophagy protein Atg8 ubiquitin like
437Prefoldin subunit
112Haemolysin-III related
123Glycerophosphoryl diester phosphodiesterase family
5959PFEMP DBL domain
11Male sterility protein
11Exostosin family
11Folate receptor family
61016Dynein heavy chain region D6 P-loop domain
336Conserved hypothetical ATP binding protein
213Inorganic H+ pyrophosphatase
4812NLI interacting factor-like phosphatase
123Phosphatidyl serine synthase
112tRNA methyl transferase
134MBOAT, membrane-bound O-acyltransferase family
11GNT-I family
112Glutamate-cysteine ligase
112Sugar efflux transporter for intercellular exchange
11Strictosidine synthase
112CutA1 divalent ion tolerance protein
279BT1 family
112Phosphotyrosyl phosphate activator (PTPA) protein
11BRO1-like domain
538Biotin/lipoate A/B protein ligase family
235DNA polymerase family B, exonuclease domain
235SPX domain
257ABC1 family
11NAD-dependent DNA ligase OB-fold domain
112Herpesviridae UL52/UL70 DNA primase
112EXS family
11Plus-3 domain
459Anticodon binding domain
279Tubulin-tyrosine ligase family
224TB2/DP1, HVA22 family
5611Elongation factor Tu C-terminal domain
131225Elongation factor Tu domain 2
213Ferredoxin-fold anticodon binding domain
448Triose-phosphate Transporter family
325Ubiquitin fusion degradation protein UFD1
11Transcription factor IIA, alpha/beta subunit
22ALG6, ALG8 glycosyltransferase family
347XRN 5'-3' exonuclease N-terminus
112Trafficking protein Mon1
112Uracil DNA glycosylase superfamily
112OG-Fe(II) oxygenase superfamily
235CPSF A subunit region
224Vacuolar (H+)-ATPase G subunit
123LUC7 N_terminus
112Eukaryotic glutathione synthase
11Glycosyl hydrolase family 63 C-terminal domain
112MerC mercury resistance protein
22Molybdopterin guanine dinucleotide synthesis protein B
11PRA1 family protein
11Rad17 P-loop domain
11Tc5 transposase DNA-binding domain
112V-ATPase subunit C
112V-ATPase subunit H
112Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
22Gamma interferon inducible lysosomal thiol reductase (GILT)
11Pneumovirus nucleocapsid protein
112Rer1 family
112Anaphase-promoting complex, subunit 10 (APC10)
224Roadblock/LC7 domain
123EB1-like C-terminal motif
112mRNA capping enzyme
112S25 ribosomal protein
112Eukaryotic phosphomannomutase
112SART-1 family
112Daxx N-terminal Rassf1C-interacting domain
112Oligosaccharyltransferase 48 kDa subunit beta
112Polyketide cyclase / dehydrase and lipid transport
112YEATS family
112ZPR1 zinc-finger domain
224PRP38 family
81220Endonuclease/Exonuclease/phosphatase family
112CAS/CSE protein, C-terminus
347LEM3 (ligand-effect modulator 3) family / CDC50 family
112Legume-like lectin family
11Regulator of Vps4 activity in the MVB pathway
336SAC3/GANP family
11Mo-co oxidoreductase dimerisation domain
11Clostripain family
112Peptidase family C54
112Saccharopine dehydrogenase NADP binding domain
112Early transcription elongation factor of RNA pol II, NGN section
112FAD binding domain of DNA photolyase
145NAD binding domain of 6-phosphogluconate dehydrogenase
11MoeA N-terminal region (domain I and II)
325PCRF domain
224eRF1 domain 1
224eRF1 domain 2
224eRF1 domain 3
112Smg-4/UPF3 family
112ATP cone domain
112Putative GTP-binding controlling metal-binding
112B3/4 domain
112tRNA synthetase B5 domain
112Arginyl tRNA synthetase N terminal domain
123Calcium-activated BK potassium channel alpha subunit
112Plectin/S10 domain
112Regulator of volume decrease after cellular swelling
112Structure-specific recognition protein (SSRP1)
112Transcription initiation factor TFIID 23-30kDa subunit
11Cullin binding
22Allantoicase repeat
11Peptidase family C50
11Peptidase family S58
213EMG1/NEP1 methyltransferase
112Leucyl/phenylalanyl-tRNA protein transferase
112Conserved hypothetical protein 95
112DNA directed RNA polymerase, 7 kDa subunit
33Organic solute transporter Ostalpha
112Vacuolar protein sorting-associated protein 35
22Mob1/phocein family
11Glycosyl hydrolase family 81 N-terminal domain