Annotations/Genomes | Total | Annotation Description | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Merops | 402 | 339 | 299 | 374 | 316 | 450 | 354 | 368 | 307 | 3,209 | |
58 | 41 | 39 | 52 | 43 | 69 | 62 | 41 | 35 | 440 | Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms | |
2 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 15 | Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane. | |
16 | 12 | 19 | 22 | 14 | 17 | 16 | 12 | 15 | 143 | Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence | |
15 | 10 | 7 | 8 | 4 | 7 | 3 | 7 | 6 | 67 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |
2 | 2 | 1 | 1 | 1 | 5 | 2 | 14 | Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence | |||
3 | 3 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |||||||||
34 | 11 | 15 | 60 | Water nucleophile; water bound by Gln and Glu; all endopeptidases | |||||||
9 | 13 | 6 | 9 | 10 | 4 | 5 | 10 | 6 | 72 | Families of peptidase inhibitors not assigned to clans | |
1 | 5 | 6 | |||||||||
1 | 1 | ||||||||||
1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 9 | ||
4 | 6 | 4 | 3 | 3 | 2 | 4 | 4 | 5 | 35 | ||
3 | 3 | 2 | 2 | 1 | 3 | 3 | 2 | 2 | 21 | Families of metallopeptidases not assigned to clans | |
17 | 17 | 16 | 17 | 14 | 15 | 9 | 14 | 17 | 136 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp | |
1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 9 | Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His | |
1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 8 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu | ||
1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 9 | Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu | |
8 | 9 | 9 | 11 | 11 | 8 | 9 | 8 | 9 | 82 | Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu | |
20 | 15 | 14 | 14 | 20 | 14 | 15 | 15 | 12 | 139 | Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His | |
10 | 10 | 9 | 16 | 12 | 11 | 10 | 13 | 10 | 101 | Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His. | |
1 | 1 | 1 | 1 | 1 | 1 | 1 | 7 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site. | |||
1 | 1 | 1 | 1 | 4 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH) | ||||||
6 | 5 | 5 | 6 | 6 | 6 | 6 | 6 | 5 | 51 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D) | |
1 | 1 | Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases | |||||||||
21 | 23 | 23 | 26 | 23 | 19 | 22 | 21 | 22 | 200 | Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme | |
7 | 6 | 5 | 6 | 8 | 6 | 6 | 8 | 6 | 58 | Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence. | |
5 | 11 | 14 | 14 | 11 | 17 | 12 | 19 | 13 | 116 | Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs | |
152 | 125 | 97 | 134 | 105 | 147 | 127 | 131 | 105 | 1,123 | Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence | |
7 | 2 | 4 | 4 | 4 | 2 | 3 | 3 | 4 | 33 | Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence | |
3 | 2 | 2 | 3 | 3 | 2 | 2 | 3 | 2 | 22 | Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence | |
2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 9 | Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence | ||
4 | 2 | 4 | 4 | 4 | 1 | 4 | 3 | 4 | 30 | Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane | |
1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 9 | ||
25 | 14 | 11 | 13 | 10 | 53 | 14 | 17 | 19 | 176 |