Annotations/Genomes | Total | Annotation Description | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Merops | 422 | 311 | 304 | 284 | 376 | 253 | 238 | 232 | 290 | 272 | 2,982 | |||
31 | 25 | 24 | 28 | 35 | 20 | 20 | 20 | 33 | 22 | 258 | Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms | |||
10 | 3 | 4 | 4 | 5 | 4 | 3 | 4 | 4 | 3 | 44 | Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane. | |||
40 | 35 | 35 | 29 | 45 | 29 | 30 | 28 | 28 | 24 | 323 | Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence | |||
6 | 5 | 6 | 7 | 8 | 6 | 4 | 6 | 4 | 2 | 54 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |||
16 | 1 | 2 | 3 | 3 | 2 | 2 | 1 | 2 | 32 | Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence | ||||
1 | 1 | 2 | Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence | |||||||||||
1 | 2 | 1 | 1 | 1 | 2 | 8 | Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence | |||||||
2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 15 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |||
9 | 7 | 7 | 6 | 12 | 7 | 7 | 7 | 13 | 6 | 81 | Families of peptidase inhibitors not assigned to clans | |||
1 | 1 | |||||||||||||
1 | 1 | 2 | 1 | 1 | 6 | |||||||||
1 | 1 | 2 | ||||||||||||
1 | 1 | |||||||||||||
2 | 1 | 2 | 5 | |||||||||||
1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 13 | ||||
5 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 18 | ||||
1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 10 | Families of metallopeptidases not assigned to clans | ||||
26 | 16 | 23 | 17 | 28 | 18 | 15 | 15 | 18 | 22 | 198 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp | |||
2 | 2 | Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His | ||||||||||||
3 | 4 | 1 | 1 | 1 | 10 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu | ||||||||
4 | 5 | 4 | 3 | 8 | 4 | 4 | 4 | 4 | 3 | 43 | Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu | |||
15 | 11 | 13 | 12 | 16 | 14 | 11 | 12 | 13 | 11 | 128 | Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu | |||
16 | 17 | 11 | 15 | 14 | 11 | 11 | 10 | 16 | 17 | 138 | Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His | |||
11 | 7 | 12 | 9 | 5 | 6 | 5 | 4 | 4 | 10 | 73 | Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His. | |||
1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 11 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site. | ||||
7 | 3 | 6 | 5 | 10 | 6 | 5 | 6 | 6 | 2 | 56 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D) | |||
3 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 3 | 16 | Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases | |||
35 | 20 | 23 | 17 | 31 | 17 | 19 | 19 | 32 | 18 | 231 | Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme | |||
4 | 5 | 3 | 3 | 5 | 3 | 2 | 2 | 3 | 3 | 33 | Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence. | |||
1 | 1 | 1 | 3 | Serine or threonine nucleophile; N-terminal nucleophile | ||||||||||
22 | 15 | 10 | 19 | 15 | 11 | 8 | 8 | 18 | 10 | 136 | Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs | |||
96 | 82 | 67 | 55 | 70 | 46 | 52 | 48 | 53 | 71 | 640 | Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence | |||
1 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 11 | Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence | |||||
7 | 4 | 5 | 4 | 7 | 6 | 5 | 5 | 2 | 3 | 48 | Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence | |||
3 | 1 | 4 | Serine nucleophile; catalytic residues in the order Ser, Lys in sequence | |||||||||||
2 | 1 | 3 | 3 | 1 | 1 | 1 | 2 | 1 | 2 | 17 | Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence | |||
11 | 6 | 7 | 7 | 9 | 6 | 5 | 4 | 4 | 4 | 63 | Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane | |||
2 | 1 | 1 | 1 | 1 | 1 | 7 | Families of peptidases of unknown catalytic mechanism not assigned to clans | |||||||
2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 12 | ||||
26 | 23 | 24 | 26 | 24 | 24 | 20 | 17 | 23 | 17 | 224 | ||||
1 | 1 | 1 | 3 | |||||||||||
1 | 1 | |||||||||||||
1 | 1 |