Annotations/Genomes | Total | Annotation Description | |||||||
---|---|---|---|---|---|---|---|---|---|
Merops | 377 | 317 | 367 | 364 | 376 | 352 | 433 | 2,586 | |
63 | 46 | 54 | 49 | 54 | 49 | 62 | 377 | Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms | |
2 | 2 | 2 | 2 | 2 | 1 | 1 | 12 | Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane. | |
14 | 11 | 14 | 12 | 11 | 11 | 15 | 88 | Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence | |
9 | 5 | 3 | 3 | 4 | 4 | 4 | 32 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |
1 | 1 | 2 | 1 | 2 | 7 | Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence | |||
1 | 1 | Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence | |||||||
1 | 1 | 2 | 2 | 2 | 2 | 1 | 11 | Water nucleophile; water bound by Gln and Glu; all endopeptidases | |
2 | 2 | 2 | 2 | 2 | 2 | 2 | 14 | Families of peptidase inhibitors not assigned to clans | |
1 | 1 | 1 | 3 | ||||||
2 | 2 | 2 | 2 | 2 | 2 | 2 | 14 | ||
2 | 2 | 2 | 2 | 2 | 2 | 2 | 14 | Families of metallopeptidases not assigned to clans | |
17 | 14 | 16 | 18 | 18 | 17 | 22 | 122 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp | |
1 | 1 | 1 | 1 | 1 | 1 | 6 | Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His | ||
1 | 1 | 1 | 1 | 2 | 1 | 7 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu | ||
1 | 1 | 3 | 5 | Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu | |||||
9 | 11 | 10 | 10 | 11 | 8 | 9 | 68 | Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu | |
15 | 17 | 14 | 17 | 14 | 17 | 15 | 109 | Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His | |
10 | 12 | 11 | 11 | 11 | 11 | 12 | 78 | Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His. | |
1 | 1 | 1 | 1 | 1 | 1 | 6 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site. | ||
1 | 1 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH) | |||||||
5 | 5 | 6 | 6 | 6 | 5 | 7 | 40 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D) | |
1 | 1 | Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases | |||||||
24 | 18 | 22 | 22 | 22 | 23 | 22 | 153 | Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme | |
4 | 4 | 5 | 5 | 5 | 5 | 5 | 33 | Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence. | |
22 | 25 | 27 | 26 | 29 | 25 | 34 | 188 | Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs | |
149 | 117 | 147 | 144 | 145 | 142 | 178 | 1,022 | Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence | |
4 | 5 | 3 | 4 | 4 | 4 | 6 | 30 | Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence | |
3 | 3 | 3 | 3 | 5 | 3 | 4 | 24 | Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence | |
1 | 1 | 1 | 1 | 1 | 1 | 6 | Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence | ||
2 | 2 | 3 | 3 | 4 | 4 | 3 | 21 | Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane | |
1 | 1 | Families of peptidases of unknown catalytic mechanism not assigned to clans | |||||||
1 | 1 | 1 | 1 | 1 | 1 | 1 | 7 | ||
10 | 9 | 12 | 13 | 14 | 8 | 13 | 79 | ||
1 | 1 | ||||||||
1 | 1 | 1 | 2 | 5 |